Biomarkers & Organ Function¶
Biomarker Overview¶
| Biomarker | Organ/System | Species | Normal Range |
|---|---|---|---|
| CRP | Inflammation | Canine | < 10 mg/L |
| SAA | Inflammation | Feline | < 5 µg/mL |
| SDMA | Kidney | Canine/Feline | 0–14 µg/dL |
| NT-proBNP | Heart | Canine/Feline | < 900 pmol/L (canine) |
| Cystatin C | Kidney | Canine | Assay-specific |
| cPL/fPL | Pancreas | Canine/Feline | Assay-specific |
Renal — SDMA vs Creatinine¶
| Attribute | SDMA | Creatinine |
|---|---|---|
| Muscle-mass dependent | No | Yes |
| Early GFR loss detection | ~40% | ~75% |
| IRIS staging | Yes | Yes |
Cardiac — NT-proBNP¶
| NT-proBNP (pmol/L) | Interpretation |
|---|---|
| < 900 | Normal |
| 900–1800 | Grey zone — echo |
| > 1800 | Significant heart disease |
Explore This Domain¶
- SDMA & Kidney Disease — early CKD detection and IRIS staging
- NT-proBNP & Heart Disease — cardiac vs non-cardiac dyspnea
- CRP & SAA Inflammation — inflammatory monitoring
FAQ¶
Which biomarker for early kidney disease? SDMA — rises at ~40% GFR loss, earlier than creatinine, and is unaffected by muscle mass.
How do I monitor inflammation? Serial CRP (canine) or SAA (feline) tracks therapy response.
What does NT-proBNP tell me? Whether dyspnea/cough is cardiac vs non-cardiac in origin.
For structured data cards, see the Data Hub.
Authored by: Migibio Clinical & Scientific Affairs, Guangzhou Magic Biotech Co., Ltd.
Reviewed by: Migibio R&D Quality Committee
Last updated: 2026-08-13
Disclosure: Migibio (Guangzhou Magic Biotech Co., Ltd.) is the manufacturer of the FIA680/FIA880 analyzers and FICT reagents referenced in this content. See our Editorial & Review Policy.
Contact: Martin.Wong · Phone (WhatsApp): +86 13323237275 · Email: martinwang2024@gmail.com